Unique circulating cytokine profile of rheumatoid arthritis patients with nodules
نویسندگان
چکیده
منابع مشابه
Exaggerated circulating Th-1 cytokine response in early rheumatoid arthritis patients with nodules.
BACKGROUND Immunohistochemical studies of the rheumatoid nodule (RN) suggest it is a Th1 granuloma, with focal vasculitis, yet the pathogenesis remains unclear and little is known about circulating cytokines in these patients. OBJECTIVE We studied circulating cytokines in DMARD-naïve RA patients to investigate associations with subcutaneous RN. METHODS 149 DMARD-naïve adults with early RA (...
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Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with different extra-articular manifestations. Among those extra-articular manifestations, there are significant cutaneous manifestations which may result in first admission to a dermatologist. In this article some specific and non-specific skin lesions of RA such as rheumatoid nodules, exacerbated nodules, rheumatoid vascu...
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Interleukin 1 (IL-1), IL-6, and tumour necrosis factor (TNF) alpha are pleiotropic cytokines produced predominantly by macrophages which have been implicated in the pathogenesis of rheumatoid arthritis (RA). Sulphasalazine has been shown to have disease modifying properties and to inhibit the production of cytokines in vitro. To evaluate the effect of sulphasalazine on cytokine production in vi...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2011
ISSN: 1479-5876
DOI: 10.1186/1479-5876-9-s2-p48